Abca2^tm1Kdt
Targeted Allele Detail

Summary

• Symbol: Abca2^tm1Kdt
• Name: ATP-binding cassette, sub-family A member 2; targeted mutation 1, Kenneth D Tew
• MGI ID: MGI:3697467
• Synonyms: Abca2^-
• Gene: Abca2 Location: Chr2:25318715-25338552 bp, + strand Genetic Position: Chr2, 17.25 cM, cytoband A2-B
• Alliance: Abca2^tm1Kdt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117673
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 23-30 were replaced with a neomycin resistance cassette. This sequence encoded the first nucleotide binding domain. (J:117673)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abca2 Mutation: 75 strains or lines available

References

• Original: J:117673 Mack JT, et al., 'Skittish' Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system. Mol Cell Biol. 2007 Jan;27(1):44-53
• All: 3 reference(s)