Lyve1^tm1Dgjk
Targeted Allele Detail

Summary

• Symbol: Lyve1^tm1Dgjk
• Name: lymphatic vessel endothelial hyaluronan receptor 1; targeted mutation 1, David G Jackson
• MGI ID: MGI:3697676
• Synonyms: Lyve-1^-
• Gene: Lyve1 Location: Chr7:110449814-110462160 bp, - strand Genetic Position: Chr7, 57.89 cM, cytoband F2
• Alliance: Lyve1^tm1Dgjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117678
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a TM-lacZ gene and a neomycin selection gene into the locus, replacing the coding sequence spanning from exon 2 to exon 5. The first 32 amino acids fused to the TM-lacZ after splicing. Staining confirmed expression of lacZ under the control of the endogenous promoter. (J:117678)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyve1 Mutation: 15 strains or lines available

References

• Original: J:117678 Gale NW, et al., Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1. Mol Cell Biol. 2007 Jan;27(2):595-604
• All: 4 reference(s)