Ppp4c^tm1Tht
Targeted Allele Detail

Summary

• Symbol: Ppp4c^tm1Tht
• Name: protein phosphatase 4, catalytic subunit; targeted mutation 1, Tse-Hua Tan
• MGI ID: MGI:3697685
• Synonyms: PP4^flox
• Gene: Ppp4c Location: Chr7:126385038-126391668 bp, - strand Genetic Position: Chr7, 69.25 cM
• Alliance: Ppp4c^tm1Tht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117684
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 3. A neo included in the vector was subsequently removed via FLP mediated recombination. (J:117684)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp4c Mutation: 41 strains or lines available

References

• Original: J:117684 Shui JW, et al., Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Mol Cell Biol. 2007 Jan;27(1):79-91
• All: 4 reference(s)