Sulf2^{Gt(XST155)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Sulf2^{Gt(XST155)Byg}
• Name: sulfatase 2; gene trap XST155, BayGenomics
• MGI ID: MGI:3697687
• Synonyms: Sulf2^-, Sulf2^{GT(pGT1TMpfs)155Ska}, SULF2^TMBeta
• Gene: Sulf2 Location: Chr2:165915819-165997603 bp, - strand Genetic Position: Chr2, 86.31 cM, cytoband H3
• Alliance: Sulf2^{Gt(XST155)Byg} page

Mutation origin

• Mutant Cell Line: XST155
• Germline Transmission: Earliest citation of germline transmission: J:117689
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT1TMpfs
• Mutation details: A gene trap containing the pGT1TMpfs vector was inserted into intron 5. The resulting protein lacked the C-terminal 629 amino acids including the catalytic cysteine essential for sulfatase activity and a hydrophilic domain necessary for sulfatase activity and HS binding. (J:117689)

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sulf2 Mutation: 177 strains or lines available

Notes

ES Cell line = E14Tg2a.4

References

• Original: J:117689 Lum DH, et al., Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2. Mol Cell Biol. 2007 Jan;27(2):678-88
• All: 2 reference(s)