Lyve1^tm1Lhua
Targeted Allele Detail

Summary

• Symbol: Lyve1^tm1Lhua
• Name: lymphatic vessel endothelial hyaluronan receptor 1; targeted mutation 1, Jung S Huang
• MGI ID: MGI:3697727
• Synonyms: Crsbp-1^-
• Gene: Lyve1 Location: Chr7:110449814-110462160 bp, - strand Genetic Position: Chr7, 57.89 cM, cytoband F2
• Alliance: Lyve1^tm1Lhua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117713
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to remove parts of exon 2, intron 2, exon 3 and intron 3 of the gene, and also to create a frame shift. The vector contained a floxed cassette containing a neomycin resistance gene and a testes specific angiotensin-converting enzyme promoter driving expression of cre recombinase. The floxed cassette was excised from the locus upon passage through the male germline. (J:117713)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lyve1 Mutation: 15 strains or lines available

References

• Original: J:117713 Huang SS, et al., CRSBP-1/LYVE-l-null mice exhibit identifiable morphological and functional alterations of lymphatic capillary vessels. FEBS Lett. 2006 Nov 13;580(26):6259-68
• All: 3 reference(s)