Bmd27^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bmd27^C57BL/6J
• Name: bone mineral density 27; C57BL/6J
• MGI ID: MGI:3697883
• QTL: Bmd27 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for the genome scan. Parental strain C57BL/6J displays decreased activity and increased body weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

On mouse Chromosome 1, linkage to bone mineral density mapped to 96 cM with LOD=4.17. This locus is named Bmd27. Bmd36 mapped to 99 cM in linkage to bone mineral density in females(LOD=3.98).

References

• Original: J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• All: 1 reference(s)