Tgif1^tm1Ychn
Targeted Allele Detail

Summary

• Symbol: Tgif1^tm1Ychn
• Name: TGFB-induced factor homeobox 1; targeted mutation 1, Yan Chen
• MGI ID: MGI:3698004
• Synonyms: Tgif^deltaexon3
• Gene: Tgif1 Location: Chr17:71151200-71160527 bp, - strand Genetic Position: Chr17, 41.87 cM
• Alliance: Tgif1^tm1Ychn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117761
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neomycin resistance cassette by homologous recombination. Western blot confirmed absence of protein in mutant brain samples. (J:117761)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgif1 Mutation: 52 strains or lines available

References

• Original: J:117761 Kuang C, et al., Intragenic deletion of Tgif causes defectsin brain development. Hum Mol Genet. 2006 Dec 15;15(24):3508-19
• All: 1 reference(s)