Gba1^tm1.1Clk
Targeted Allele Detail

Summary

• Symbol: Gba1^tm1.1Clk
• Name: glucosylceramidase beta 1; targeted mutation 1.1, Lorne A Clarke
• MGI ID: MGI:3698019
• Synonyms: deltaGBA
• Gene: Gba1 Location: Chr3:89110235-89116273 bp, + strand Genetic Position: Chr3, 39.01 cM
• Alliance: Gba1^tm1.1Clk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117763
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated recombination removed floxed sequence containing exons 9-11, leaving metataxin exons 8-4. (J:117763)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gba1 Mutation: 47 strains or lines available

References

• Original: J:117763 Sinclair GB, et al., Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease. Mol Genet Metab. 2007 Feb;90(2):148-56
• All: 2 reference(s)