Spast^tm1.1Jme
Targeted Allele Detail

Summary

• Symbol: Spast^tm1.1Jme
• Name: spastin; targeted mutation 1.1, Judith Melki
• MGI ID: MGI:3698038
• Synonyms: Sp^delta
• Gene: Spast Location: Chr17:74645982-74698110 bp, + strand Genetic Position: Chr17, 45.64 cM, cytoband E3
• Alliance: Spast^tm1.1Jme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117740
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 5-7 were removed via cre-mediated excision. (J:117740)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spast Mutation: 37 strains or lines available

References

• Original: J:117740 Tarrade A, et al., A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition. Hum Mol Genet. 2006 Dec 15;15(24):3544-58
• All: 3 reference(s)