Prkn^tm1Ykt
Targeted Allele Detail

Summary

• Symbol: Prkn^tm1Ykt
• Name: parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Yasuko Kitao
• MGI ID: MGI:3698054
• Gene: Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
• Alliance: Prkn^tm1Ykt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117737
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a floxed pgk-neomycin cassette. Absence of protein was confirmed by Western blot analysis. (J:117737)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkn Mutation: 54 strains or lines available

References

• Original: J:117737 Kitao Y, et al., Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet. 2007 Jan 1;16(1):50-60
• All: 5 reference(s)