Zic3^tm1Jwb
Targeted Allele Detail

Summary

• Symbol: Zic3^tm1Jwb
• Name: zinc finger protein of the cerebellum 3; targeted mutation 1, John W Belmont
• MGI ID: MGI:3698161
• Synonyms: Zic3^neo, Zic3^null
• Gene: Zic3 Location: ChrX:57075988-57081990 bp, + strand Genetic Position: ChrX, 32.56 cM
• Alliance: Zic3^tm1Jwb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117748
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An frt-flanked neomycin resistance cassette was inserted in antisense orientation upstream of the locus. (J:117748)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zic3 Mutation: 38 strains or lines available

References

• Original: J:117748 Zhu L, et al., Craniofacial, skeletal, and cardiac defects associated with altered embryonic murine Zic3 expression following targeted insertion of a PGK-NEO cassette. Front Biosci. 2007;12:1680-90
• All: 2 reference(s)