Bmnx^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bmnx^C57BL/6J
• Name: body mass index; C57BL/6J
• MGI ID: MGI:3698187
• QTL: Bmnx Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased body mass index compared to CASA/Rk. (J:117547)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for the genome scan. Parental strain C57BL/6J displays decreased activity and increased body weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

A QTL for body mass index, designated Bmnx, mapped to 1 cM on mouse Chromosome 5 (LOD=6.34). This locus is also significant for the males-only group with LOD=5.05. Homozygosity forC57BL/6J-derived alleles at Bmnx confers increased body mass index with recessive inheritance. Linkage to retroperitoneal fat pad weight in females, named Rfpw5, mapped to 73 cM with LOD=3.6. Body weight mapped to 1 cM (Bw27, LOD=6.33) for both sexes andto 3 cM (Bw30, LOD=3.72) for females.

References

• Original: J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• All: 1 reference(s)