Lbm14^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Lbm14^C57BL/6J
• Name: lean body mass 14; C57BL/6J
• MGI ID: MGI:3698215
• QTL: Lbm14 Location: unknown Genetic Position: Chr2, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for the genome scan. Parental strain C57BL/6J displays decreased activity and increased body weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

On mouse Chromosome 2, linkage to body length (Bdln7, LOD=4), and lean body mass (Lbm11, LOD=6.13) mapped to 34 cM. Linkage to lean body mass in males mapped to 36 cM and is named Lbm14 (LOD=4.19). Linkage to body weight mapped to 34 cM (LOD=5.21) and is named Bw26. Linkage to total body fat tissue mass (Ftm1, LOD=4.2) mapped to 60 cM and linkage to abdominal fat mass mapped to 62 cM (Abfm1, LOD=4.13) and 87 cM (Abfm2, LOD=3.88). Linkage to mesenteric and omental fat pad weight mapped to 66 cM (Mofp1, LOD=4.32), and to 87 cM for males (Mofp5, LOD=3.48). Linkage to retroperitoneal fat pad weight (Rfpw1, LOD=5.14) mapped to 96 cM. Linkage to bone mineral content mapped to 40 cM (Bmc1, LOD=3.87), and to 37 cM for males (Bmc7, LOD=3.5). Linkage to bone mineral density mapped to 40 cM (Bmd28, LOD=4.09) in both sexes, and to 37 cM (Bmd32, LOD=4.34) in females.

References

• Original: J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• All: 1 reference(s)