Lrp8^tm5Her
Targeted Allele Detail

Summary

• Symbol: Lrp8^tm5Her
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 5, Joachim Herz
• MGI ID: MGI:3698275
• Synonyms: Apoer2 Stop, Apoer2[Stop]
• Gene: Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Lrp8^tm5Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117956
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A premature stop codon was inserted into the locus on a 434 cDNA encoding the intracellular domain, 5 amino acids downstream of the NFDNPVY sequence. As a result, part of exon 18 and all of exons 19 and 20, were removed. (J:117956)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp8 Mutation: 43 strains or lines available

References

• Original: J:117956 Beffert U, et al., ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol. 2006 Dec 19;16(24):2446-52
• All: 3 reference(s)