Ctsk^tm1Ypl
Targeted Allele Detail

Summary

• Symbol: Ctsk^tm1Ypl
• Name: cathepsin K; targeted mutation 1, Yi-Ping Li
• MGI ID: MGI:3698312
• Gene: Ctsk Location: Chr3:95406567-95416673 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Ctsk^tm1Ypl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117870
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 1 and 2 with a neomycin resistance cassette. Northern blot confirmed absence of transcript in mutants. (J:117870)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsk Mutation: 31 strains or lines available

References

• Original: J:117870 Chen W, et al., Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence. Hum Mol Genet. 2007 Feb 15;16(4):410-23
• All: 3 reference(s)