Thoc1^tm2.1Dwg
Targeted Allele Detail

Summary

• Symbol: Thoc1^tm2.1Dwg
• Name: THO complex 1; targeted mutation 2.1, David W Goodrich
• MGI ID: MGI:3698314
• Gene: Thoc1 Location: Chr18:9958176-9995486 bp, + strand Genetic Position: Chr18, 4.91 cM
• Alliance: Thoc1^tm2.1Dwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117869
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin selection cassette was inserted into intron 5. LoxP sites were inserted into intron 5, upstream of the first FRT site, and intron 7. The neo cassette was removed through Flp-mediated recombination. Exons 6-7 remain flanked by loxP sites. (J:117869)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thoc1 Mutation: 46 strains or lines available

References

• Original: J:117869 Wang X, et al., An allelic series for studying the mouse Thoc1 gene. Genesis. 2007 Jan;45(1):32-7
• All: 3 reference(s)