Sh3bp2^tm1Bjro
Targeted Allele Detail

Summary

• Symbol: Sh3bp2^tm1Bjro
• Name: SH3-domain binding protein 2; targeted mutation 1, Bjorn R Olsen
• MGI ID: MGI:3698401
• Synonyms: Sh3bp2^KI
• Gene: Sh3bp2 Location: Chr5:34683182-34720985 bp, + strand Genetic Position: Chr5, 17.89 cM
• Alliance: Sh3bp2^tm1Bjro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117880
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A proline to arginine mutation was inserted into exon 9 (P416R). A floxed neo included in the vector was subsequently removed from the locus. (J:117880)

Disease models

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3bp2 Mutation: 35 strains or lines available

References

• Original: J:117880 Ueki Y, et al., Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell. 2007 Jan 12;128(1):71-83
• All: 14 reference(s)