Rr98^tm1Welm
Targeted Allele Detail

Summary

• Symbol: Rr98^tm1Welm
• Name: regulatory region 98; targeted mutation 1, Wilfried Ellmeier
• MGI ID: MGI:3698402
• Synonyms: Cd8a^tm1Welm, N2
• Gene: Rr98 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr98^tm1Welm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113136
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of Cd8a enhancer 8ii, specifically cluster IV DNaseI hypersensitivity sites 4 and 5 referred to as C8ii (CIV-4,5), was deleted by homologous recombination in ES cells, leaving a neomycin selection cassette in place of the 8ii enhancer. (J:113136)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr98 Mutation: 0 strains or lines available

References

• Original: J:113136 Ellmeier W, et al., Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 2002 May;16(5):623-34
• All: 1 reference(s)