Rr100^tm2.1Welm
Targeted Allele Detail

Summary

• Symbol: Rr100^tm2.1Welm
• Name: regulatory region 100; targeted mutation 2.1, Wilfried Ellmeier
• MGI ID: MGI:3698404
• Synonyms: Cd8a^tm2.1Welm, delta1delta2
• Gene: Rr100 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Rr100^tm2.1Welm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:113136
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Rr100^tm2Welm mice were crossed to CMV-cre expressing mice to remove the floxed neo cassette. This allele therefore lacks Cd8a enhancers E8i and E8ii. (J:113136, J:126027)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr100 Mutation: 0 strains or lines available

Notes

E14.1 ES cells were targeted a second time to create Cd8a^tm2Wlm and Cd8a^tm2.1 mice.

References

• Original: J:113136 Ellmeier W, et al., Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 2002 May;16(5):623-34
• All: 5 reference(s)