Gne^tm1Sngi
Targeted Allele Detail

Summary

• Symbol: Gne^tm1Sngi
• Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; targeted mutation 1, Satoru Noguchi
• MGI ID: MGI:3698409
• Synonyms: Gne^-
• Gene: Gne Location: Chr4:44034075-44084177 bp, - strand Genetic Position: Chr4, 23.1 cM, cytoband B1
• Alliance: Gne^tm1Sngi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117854
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector was designed to replace exon 3 with a neomycin resistance gene cassette. (J:117854)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gne Mutation: 49 strains or lines available

References

• Original: J:117854 Malicdan MC, et al., A Gne knockout mouse expressing human V572L mutation develops features similar to distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy. Hum Mol Genet. 2007 Jan 15;16(2):115-28
• All: 6 reference(s)