Card9^tm1Xlin
Targeted Allele Detail

Summary

• Symbol: Card9^tm1Xlin
• Name: caspase recruitment domain family, member 9; targeted mutation 1, Xin Lin
• MGI ID: MGI:3698412
• Synonyms: Card9^-
• Gene: Card9 Location: Chr2:26242188-26250930 bp, - strand Genetic Position: Chr2, 18.87 cM
• Alliance: Card9^tm1Xlin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117799
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 1 was replaced with a neomycin resistance cassette in antisense orientation. Absence of transcript and protein were confirmed by RT-PCR and Western blot. (J:117799)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Card9 Mutation: 30 strains or lines available

References

• Original: J:117799 Hsu YM, et al., The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb;8(2):198-205
• All: 44 reference(s)