Ddb1^tm1Spg
Targeted Allele Detail

Summary

• Symbol: Ddb1^tm1Spg
• Name: damage specific DNA binding protein 1; targeted mutation 1, Stephen P Goff
• MGI ID: MGI:3698413
• Synonyms: DDB1^F
• Gene: Ddb1 Location: Chr19:10582961-10607186 bp, + strand Genetic Position: Chr19, 6.66 cM, cytoband centromere
• Alliance: Ddb1^tm1Spg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117820
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 5. In vitro expression of cre recombinase resulted in the loss of a floxed neomycin resistance cassette. (J:117820)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddb1 Mutation: 34 strains or lines available

References

• Original: J:117820 Cang Y, et al., Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell. 2006 Dec 1;127(5):929-40
• All: 20 reference(s)