Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}
Targeted Allele Detail

Summary

• Symbol: Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs}
• Name: ryanodine receptor 2, cardiac; targeted mutation 1, Noboru Suzuki
• MGI ID: MGI:3698416
• Synonyms: Ryr2^tm1Nobs
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117828
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ryr2^{tm1(CAG-KRAS*G12V,-lacZ)Nobs} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KRAS (3845)

  Kras	(MGI:96680)

  Expresses an human KRAS*G12V mutation

• Mutation details: A targeting vector was designed to replace exon 2 with a cassette containing CAG-loxP-stop-loxP-KrasG12V-IRES-NL-lacZ-pA-neo. (J:117828)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 325 strains or lines available

References

• Original: J:117828 Tsumura H, et al., Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. Oncogene. 2006 Dec 14;25(59):7673-9
• All: 2 reference(s)