Ba2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Ba2^C57BL/6J
• Name: bone area 2; C57BL/6J
• MGI ID: MGI:3698473
• QTL: Ba2 Location: unknown Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for genome scan. Parental strain C57BL/6J displays decreasedactivity and increased weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

On mouse Chromosome 9, linkage to body length (Bdln8, LOD=4.8) mapped to 59 cM. Linkage to body length in males (Bdln9, LOD=4.42) mapped to 72 cM. Linkage to lean body mass (Lbm12, LOD=5.88)mapped to 63 cM and linkage to lean body mass in males (Lbm15, LOD=5.08) mapped to 71 cM near D9Mit151. Homozygosity for C57BL/6J-derived alleles at Lbm15 confers increased lean body mass in males. Linkage to body weight in males (Bw29, LOD=4.15) mapped to 71 cM. Linkage to bone area (Ba2, LOD=5.07) mapped to 59 cM and linkage to bone area in males (Ba5, LOD=5.49) mapped to 63 cM. Linkage to bone mineral content mapped to 61 cM (Bmc4, LOD=4.96) in both sexes and to 65 cM (Bmc9, LOD=5.64) in males only. Bone mineral density in males, named Bmd34, mapped to 65 cM.

References

• Original: J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• All: 1 reference(s)