Ba4^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Ba4^C57BL/6J
• Name: bone area 4; C57BL/6J
• MGI ID: MGI:3698477
• QTL: Ba4 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for genome scan. Parental strain C57BL/6J displays decreasedactivity and increased weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

Linkage to bone area mapped to 53 cM on mouse Chromosome 7 and is named Ba1 (LOD=4.71). Linkage to bone area in males is named Ba4 and also mapped to 53 cM with LOD=4.12. Linkage to bone mineral content to 15 cM (Bmc3, LOD=4.42), and mapped to 53 cM (Bmc8, LOD=3.45) in males.

References

• Original: J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• All: 1 reference(s)