Bmc5^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Bmc5^C57BL/6J
• Name: bone mineral content 5; C57BL/6J
• MGI ID: MGI:3698487
• QTL: Bmc5 Location: unknown Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for genome scan. Parental strain C57BL/6J displays decreasedactivity and increased weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

Linkage to body weight, named Bw28, mapped to 49 cM on mouse Chromosome 13 with LOD=5.09. Linkage to lean body mass, Lbm13, mapped to 49 cM with LOD=3.81. Linkage to bone area mapped to 67 cM (Ba3, LOD=4.3) in both sexes and to 63 cM (Ba6, LOD=3.9) in females only. Linkage to bone mineral content mapped to 45 cM (Bmc5, LOD=5.31) in both sexes and to 61 cM (Bmc10, LOD=3.78) in females. Bone mineral density, Bmd30, mapped to 47 cM with LOD=5.21.

References

• Original: J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
• All: 1 reference(s)