Thbd^tm2.1Emc
Targeted Allele Detail

Summary

• Symbol: Thbd^tm2.1Emc
• Name: thrombomodulin; targeted mutation 2.1, Edward M Conway
• MGI ID: MGI:3698840
• Synonyms: TM^LeD
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^tm2.1Emc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118000
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed neo was removed from the locus, leaving a single loxP site as well as a locus lacking the NH2-terminal domain. (J:118000)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 25 strains or lines available

References

• Original: J:118000 Conway EM, et al., The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med. 2002 Sep 2;196(5):565-77
• All: 4 reference(s)