Mapkapk5^tm1Pqs
Targeted Allele Detail

Summary

• Symbol: Mapkapk5^tm1Pqs
• Name: MAP kinase-activated protein kinase 5; targeted mutation 1, Peiqing Sun
• MGI ID: MGI:3698841
• Synonyms: deltaex8, Prak^-
• Gene: Mapkapk5 Location: Chr5:121663114-121683955 bp, - strand Genetic Position: Chr5, 61.84 cM, cytoband F
• Alliance: Mapkapk5^tm1Pqs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117893
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 8. Protein was not detected in mutant mice. (J:117893)

Tumor Data

List all tumor models in MMHCdb carrying Mapkapk5^tm1Pqs

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapkapk5 Mutation: 30 strains or lines available

References

• Original: J:117893 Sun P, et al., PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007 Jan 26;128(2):295-308
• All: 6 reference(s)