Foxo1^tm1.1Rdp
Targeted Allele Detail

Summary

• Symbol: Foxo1^tm1.1Rdp
• Name: forkhead box O1; targeted mutation 1.1, Ronald DePinho
• MGI ID: MGI:3698868
• Synonyms: Foxo1^-
• Gene: Foxo1 Location: Chr3:52175758-52257530 bp, + strand Genetic Position: Chr3, 23.19 cM
• Alliance: Foxo1^tm1.1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118179
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was removed via cre-mediated recombination. Northern blot confirmed absence of transcript in mutants. (J:118179)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxo1 Mutation: 32 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Granulosa Cell Tumor of the ovary J:232961.

References

• Original: J:118179 Paik JH, et al., FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007 Jan 26;128(2):309-23
• All: 10 reference(s)