Dtl^tm1Hch
Targeted Allele Detail

Summary

• Symbol: Dtl^tm1Hch
• Name: denticleless E3 ubiquitin protein ligase; targeted mutation 1, Hey-Chi Hsu
• MGI ID: MGI:3699089
• Synonyms: L2dtl^-
• Gene: Dtl Location: Chr1:191269468-191307656 bp, - strand Genetic Position: Chr1, 96.44 cM, cytoband H6
• Alliance: Dtl^tm1Hch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118159
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The coding region of exon 1 was replaced by a floxed neomycin resistance cassette. (J:118159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dtl Mutation: 47 strains or lines available

References

• Original: J:118159 Liu CL, et al., L2dtl is essential for cell survival and nuclear division in early mouse embryonic development. J Biol Chem. 2007 Jan 12;282(2):1109-18
• All: 1 reference(s)