Apbb1^tm1Trus
Targeted Allele Detail

Summary

• Symbol: Apbb1^tm1Trus
• Name: amyloid beta precursor protein binding family B member 1; targeted mutation 1, Tommaso Russo
• MGI ID: MGI:3699106
• Synonyms: Fe65^-, Fe65 KO
• Gene: Apbb1 Location: Chr7:105207690-105230860 bp, - strand Genetic Position: Chr7, 55.9 cM
• Alliance: Apbb1^tm1Trus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118164
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a PGK-neo cassette. (J:118164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apbb1 Mutation: 52 strains or lines available

References

• Original: J:118164 Minopoli G, et al., Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage. J Biol Chem. 2007 Jan 12;282(2):831-5
• All: 3 reference(s)