Hsd11b2^tm1(cre)Anft
Targeted Allele Detail

Summary

• Symbol: Hsd11b2^tm1(cre)Anft
• Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Aniko Naray-Fejes-Toth
• MGI ID: MGI:3699113
• Synonyms: 11HSD2/iCre, Hsd11b2-Cre
• Gene: Hsd11b2 Location: Chr8:106245387-106250620 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Hsd11b2^tm1(cre)Anft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118075
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hsd11b2^tm1(cre)Anft expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hsd11b2 (MGI:104720)

• Mutation details: An improved Cre and a neomycin resistance cassette were inserted to replace the exon containing the ATG. The neo was flanked by FRT sites and subsequently removed by FLP mediated recombination. (J:118075)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hsd11b2 (mouse) Summary of all recombinase alleles driven by Hsd11b2. Comparative matrix view of recombinase activities Alliance mouse Hsd11b2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b2 Mutation: 19 strains or lines available

References

• Original: J:118075 Naray-Fejes-Toth A, et al., Novel mouse strain with Cre recombinase in 11beta-hydroxysteroid dehydrogenase-2-expressing cells. Am J Physiol Renal Physiol. 2007 Jan;292(1):F486-94
• All: 3 reference(s)