Igh^tm1(PAX5)Mbu
Targeted Allele Detail

Summary

• Symbol: Igh^tm1(PAX5)Mbu
• Name: immunoglobulin heavy chain complex; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:3699130
• Synonyms: IgH^P5ki
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118111
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace JH1-4 with a cassette containing human PAX5 and an IRES-GFP. (J:118111)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:118111 Souabni A, et al., Oncogenic role of Pax5 in the T-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus. Blood. 2007 Jan 1;109(1):281-9
• All: 1 reference(s)