Ren1^tm1Bjm
Targeted Allele Detail

Summary

• Symbol: Ren1^tm1Bjm
• Name: renin 1 structural; targeted mutation 1, Brian J Morris
• MGI ID: MGI:3699140
• Synonyms: REKO
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm1Bjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117294
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace the enhancer with a floxed pgk-neo cassette that was subsequently removed via cre-mediated recombination. (J:117294)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 35 strains or lines available

References

• Original: J:117294 Adams DJ, et al., Renin enhancer is critical for control of renin gene expression and cardiovascular function. J Biol Chem. 2006 Oct 20;281(42):31753-61
• All: 2 reference(s)