Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:3699244
• Synonyms: Cre-ER^T2, Gt(ROSA)26Sor^{tm1(cre/ESR1)Tyj}, R26-Cre-ER^T2, Rosa26^CreER, Rosa26-CreERT2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} page

Lower bone mass and reduced bone size in Gt(ROSA)26Sor^tm1(Pyy)Paba/Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} females

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118233
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• A cassette containing Cre-ERT2 was inserted into the locus. (J:118233)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities Alliance mouse Gt(ROSA)26Sor gene page

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:118233 Ventura A, et al., Restoration of p53 function leads to tumour regression in vivo. Nature. 2007 Feb 8;445(7128):661-5
• All: 537 reference(s)