Trp53^tm6Wahl
Targeted Allele Detail

Summary

• Symbol: Trp53^tm6Wahl
• Name: transformation related protein 53; targeted mutation 6, Geoffrey M Wahl
• MGI ID: MGI:3699247
• Synonyms: P53^AXXA
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm6Wahl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118244
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Proline codons 79 (CCA), 82 (CCT), 84 (CCA) and 87 (CCA) in exon 4 were changed to alanine (GCA, GCT, GCA, GCA) (p.P79A, p.P82A, p.P84A, p.P87A). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 6 was removed through subsequent Cre-mediated recombination. (J:118244)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 235 strains or lines available

References

• Original: J:118244 Toledo F, et al., Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb;27(4):1425-32
• All: 2 reference(s)