Lmtk2^tm1Tya
Targeted Allele Detail

Summary

• Symbol: Lmtk2^tm1Tya
• Name: lemur tyrosine kinase 2; targeted mutation 1, Tadashi Yamamoto
• MGI ID: MGI:3699255
• Synonyms: Brek^-
• Gene: Lmtk2 Location: Chr5:144037254-144125022 bp, + strand Genetic Position: Chr5, 82.85 cM
• Alliance: Lmtk2^tm1Tya page

Azoospermia in Lmtk2^tm1Tya/Lmtk2^tm1Tya mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118247
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 4-6 were replaced with a neomycin resistance gene. (J:118247)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmtk2 Mutation: 65 strains or lines available

References

• Original: J:118247 Kawa S, et al., Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19344-9
• All: 1 reference(s)