Dlg1^tm1Jhm
Targeted Allele Detail

Summary

• Symbol: Dlg1^tm1Jhm
• Name: discs large MAGUK scaffold protein 1; targeted mutation 1, Jeffrey H Miner
• MGI ID: MGI:3699270
• Synonyms: Dlgh1^-
• Gene: Dlg1 Location: Chr16:31482261-31692174 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Dlg1^tm1Jhm page

Dlg1^tm1Jhm/Dlg1^tm1Jhm embryos exhibit urinary tract abnormalities, including hydroephrosis

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118250
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 4 was replaced by a neomycin resistance cassette. (J:118250)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlg1 Mutation: 76 strains or lines available

Notes

ES cell line = F1BS

References

• Original: J:118250 Mahoney ZX, et al., Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19872-7
• All: 7 reference(s)