Flna^tm1.2Caw
Targeted Allele Detail

Summary

• Symbol: Flna^tm1.2Caw
• Name: filamin, alpha; targeted mutation 1.2, Christopher A Walsh
• MGI ID: MGI:3699306
• Synonyms: FlnA^-, Flna^K
• Gene: Flna Location: ChrX:73267067-73293426 bp, - strand Genetic Position: ChrX, 37.89 cM
• Alliance: Flna^tm1.2Caw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118252
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Crossing Flna^tm1.1Caw females with males expressing a beta-actin cre transgene results in deletion of exons 3-7. Cre recombination in floxed ES cells to produce null mutants is inefficient because the cells are male-derived and deletion of the x-linked gene results in embryonic lethality. (J:118252)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flna Mutation: 19 strains or lines available

References

• Original: J:118252 Feng Y, et al., Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41
• All: 6 reference(s)