Il22^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Il22^tm1.1Lex
• Name: interleukin 22; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:3699310
• Synonyms: IL22^-
• Gene: Il22 Location: Chr10:118040847-118045952 bp, + strand Genetic Position: Chr10, 66.67 cM
• Alliance: Il22^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 1-4 were flanked by loxP sites and subsequently deleted by cre-mediated recombination. (J:118261)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il22 Mutation: 29 strains or lines available

Notes

See data as provided by Lexicon Genetics, Inc.

References

• Original: J:118261 Zheng Y, et al., Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature. 2007 Feb 8;445(7128):648-51
• All: 63 reference(s)