Pif1^tm1Leah
Targeted Allele Detail

Summary

• Symbol: Pif1^tm1Leah
• Name: PIF1 5'-to-3' DNA helicase; targeted mutation 1, Lea Harrington
• MGI ID: MGI:3699312
• Synonyms: mPif1^-
• Gene: Pif1 Location: Chr9:65494442-65503249 bp, + strand Genetic Position: Chr9, 35.4 cM
• Alliance: Pif1^tm1Leah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118302
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to delete a region that spanned the first five conserved helicase motifs, starting near the end of exon 3 and deleting the next five exons (amino acids 222 to 407). (J:118302)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pif1 Mutation: 28 strains or lines available

References

• Original: J:118302 Snow BE, et al., Murine Pif1 interacts with telomerase and is dispensable for telomere function in vivo. Mol Cell Biol. 2007 Feb;27(3):1017-26
• All: 3 reference(s)