Fgfr2^tm2Schl
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm2Schl
• Name: fibroblast growth factor receptor 2; targeted mutation 2, Joseph Schlessinger
• MGI ID: MGI:3699314
• Synonyms: Fgfr2^CLR, Fgfr2^LR
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm2Schl page

Cleft palate, tracheal defects and joint analysis in Fgfr2^tm1Schl/Fgfr2^tm1Schl and Fgfr2^tm2Schl/Fgfr2^tm2Schl mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118299
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: Cysteine 342 was changed to tyrosine in exon 9. Leucine 424 and arginine 426 were changed to alanines in exon 10. A floxed neo was inserted into intron 9 and subsequently removed by cre mediated recombination. (J:118299)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:118299 Eswarakumar VP, et al., Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18603-8
• All: 7 reference(s)