Tg(CASP3)18Fine
Transgene Detail

Summary

• Symbol: Tg(CASP3)18Fine
• Name: transgene insertion 18, Lorraine Kerr
• MGI ID: MGI:3699361
• Synonyms: Tg(CASP3)F18Fine
• Transgene: Tg(CASP3)18Fine Location: unknown
• Alliance: Tg(CASP3)18Fine page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CASP3)18Fine expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CASP3 (836)

  Casp3

  (MGI:107739)

• Mutation details: A human genomic YAC clone (35EB2) that encompasses the caspase 3 gene was used to create the transgene. This construct contains all seven exons of the gene and the 3' untranslated region (UTR) of human caspase 3, as well as 80 kb of upstream and 50 kb of downstream regulatory sequences. Expression of the line F18 transgene is essentially identical to that of the murine protein with highest levels being detected in the spleen, thymus, liver, kidney and brain. An additional line, F57, was also created. (J:101696)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:101696 Kerr LE, et al., Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia. Cell Death Differ. 2004 Oct;11(10):1102-11
• All: 3 reference(s)