Chldq1^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Chldq1^MRL/MpJ
• Name: cholesterol and HDL QTL 1; MRL/MpJ
• MGI ID: MGI:3699393
• QTL: Chldq1 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 72.52 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased serum total cholesterol and HDL in females compared to SJL/J. (J:106033)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Chldq1 exhibits additive inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:106033

Linkage analysis was performed on 621 female mice from a (MRL/MpJ x SJL/J)F2 intercross to identify QTLs associated with obesity and serum lipid levels. Parental strain MRL/MpJ displays increased body weight, fat mass, serum cholesterol, and serum HDL, and decreased serum triglycerides compared to parental strain SJL/J. Female F2 mice were phenotyped at 7 weeks of age and genotyped at 132 polymorphic loci.

Significant linkage to serum cholesterol and HDL mapped to 95 cM on mouse Chromosome 1 near D1Mit453. This locus is named Chldq1 (cholesterol and HDL QTL 1). MRL/MpJ-derived alleles at Chdlq1 confer increased serum cholesterol and HDL with additive inheritance. Tbbmd1 (110 cM) is a femur bone mineral density QTL mapping near Chldq1, and Apoa2 at 92.6cM is a potential candidate gene. Linkage to serum triglycerides mapped to 76.2 cM near D1Mit43 (LOD=3.8) and is named Tglq1 (triglyceride QTL 1). This locus explains 3.4% of the serum triglyceride variance in females. MRL/MpJ-derived alleles at Tglq1 confer increased serum triglyceride levels with dominant inheritance.

Significant linkage to serum cholesterol (LOD=6.61) and HDL (LOD=7.02) mapped to 40 cM on mouse Chromosome 3 near D3Mit217. This locus is named Chldq2 (cholesterol and HDL QTL 2). MRL/MpJ-derived alleles at Chldq2 confer increased serum cholesterol and HDL with additive inheritance.

Significant linkage to serum cholesterol (LOD=3.32) and HDL (LOD=4.86) mapped to 45 cM - 55 cM on mouse Chromosome 5 near D5Mit239. This locus, Chldq3 (cholesterol and HDL QTL 3), also exhibits suggestive linkage to triglycerides at 55 cM (LOD=3.05). MRL/MpJ-derived alleles at Chldq3 confer increased serum cholesterol and HDL with additive inheritance.

Suggestive linkage to fat mass mapped to 50 cM on mouse Chromosome 7 (LOD=2.42). Significant linkage to non-HDL cholesterol mapped to 15 cM with LOD=3.69. This locus, Chldq4 (cholesterol and HDL QTL 4), also exhibits linkage to serum cholesterol (LOD=4.74) and HDL (LOD=2.95) at 10 cM. MRL/MpJ-derived allelesat Chldq4 confer increased serum cholesterol and HDL with additive inheritance.

Suggestive linkage to non-HDL cholesterol mapped to 40 cM on mouse Chromosome 9 with LOD=2.73.

Linkage to fat mass mapped to 43 cM on mouse Chromosome 11 near D11Mit36 (LOD=11.51). This locus is the previously identified QTL Lgth6 (body length 6). Lgth6 explains 12% of the variance for female fat mass. MRL/MpJ-derived alleles at Lgth6 confer increased fat mass with additive inheritance. Potential candidate genes for Lgth6 include Nos2 (45.2 cM), Hcrt (61.2 cM), Alox12 (40 cM), Alox3, Alox15 (40 cM), Alox12b (37 cM), and Alox12e (40 cM).

Linkage to non-HDL cholesterol mapped to 5 cM on mouse Chromosome 12 with LOD=5.09. This locus explains 6.2% of the variance and is named Nhq1 (non-HDL cholesterol QTL 1). Linkage to serum triglycerides mapped to 26 cM near D12Mit201 (LOD=4.1). This locus explains 4.6% of the variance and is named Tglq2 (triglyceride QTL 2). SJL/J-derived alleles at Tglq2 confer increased serum triglycerides in female animals with an additive mode of inheritance. Mwq4 (20 cM), Swq2 (22 cM), and Afw10 (21 cM) are previously identified obesity QTLs mapping near Tglq2.

Suggestive linkage to serum cholesterol (LOD=2.62) and HDL (LOD=2.43) mapped to 40 cM -45 cM on mouse Chromosome 14. This locus explains 2.9% of the cholesterol variance and 2.6% of the HDL variance in females.

On mouse Chromosome 16, significant linkage to fat mass mapped to 50 cM near D16Mit51 (LOD=3.99). This locus explains 3.6% of thevariance and is named Ftms1 (fat mass 1). SJL/J-derived alleles at Ftms1 confer increased fat mass with recessive inheritance. Liph (14.8 cM) is a potential candidate gene for Ftms1.

Linkage to serum cholesterol mapped to 25 cM on mouse Chromosome 17 with LOD=3.73). This locus, Chldq5 (cholesterol and HDL QTL 5), also exhibits suggestive linkage to HDL cholesterol (LOD=2.5) and triglycerides (LOD=2.59).

References

• Original: J:106033 Srivastava AK, et al., Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice. J Lipid Res. 2006 Jan;47(1):123-33
• All: 1 reference(s)