Syt7^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syt7^tm1Sud
• Name: synaptotagmin VII; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3699518
• Synonyms: C2AB KI/KO
• Gene: Syt7 Location: Chr19:10366454-10430544 bp, + strand Genetic Position: Chr19, 6.58 cM, cytoband B
• Alliance: Syt7^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118318
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Point mutations D225A, D227A, and D233A in exon 11 (previously identified as 12), and mutations D303A, D357A, and D359A in exon 13, along with a floxed neomycin resistance gene in the intervening intron were introduced in the Syt7 locus. No protein is detected by Western blot. (J:118318, J:131423)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syt7 Mutation: 41 strains or lines available

References

• Original: J:118318 Sudhof TC, A knock-in mutation of Syt7. MGI Direct Data Submission. 2007
• All: 18 reference(s)