Kcne2^tm1Gwab
Targeted Allele Detail

Summary

• Symbol: Kcne2^tm1Gwab
• Name: potassium voltage-gated channel, Isk-related subfamily, gene 2; targeted mutation 1, Geoffrey W Abbott
• MGI ID: MGI:3699589
• Synonyms: Kcne2^-
• Gene: Kcne2 Location: Chr16:92089277-92095017 bp, + strand Genetic Position: Chr16, 53.55 cM
• Alliance: Kcne2^tm1Gwab page

Kcne2^tm1Gwab/Kcne2^tm1Gwab mice have enlarged stomachs

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116518
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin resistance cassette. Western blot confirmed absence of protein in mutant stomach samples. (J:116518)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Kcne2^tm1Gwab

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcne2 Mutation: 10 strains or lines available

References

• Original: J:116518 Roepke TK, et al., The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18;281(33):23740-7
• All: 14 reference(s)