Tg(Rb1)1Blg
Transgene Detail

Summary

• Symbol: Tg(Rb1)1Blg
• Name: transgene insertion 1, Brenda L Gallie
• MGI ID: MGI:3699596
• Synonyms: mgRB, RBlox1, RBlox2, Tg(Rb1)#Blg
• Transgene: Tg(Rb1)1Blg Location: unknown
• Alliance: Tg(Rb1)1Blg page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rb1)1Blg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rb1 (MGI:97874)

• Mutation details: This transgene consists of the 1.3-kb murine Rb1 promoter region, the first exon and intron fused, in frame, to exons 2 to 27 of the mouse Rb1 cDNA and a human growth hormone cassette that provides splicing and polyadenylation signals at the 3' end. LoxP sites were inserted into the first intron and between the Rb1 stop codon and the human growth hormone, in a tandem orientation, to allow excision in the presence of Cre recombinase. Only low levels of protein were expressed, demonstrating that this transgene is hypomorphic. Six founders were generated and line 1 was selected as the representative line. (J:37145, J:98518)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:37145 Zacksenhaus E, et al., pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev. 1996 Dec 1;10(23):3051-64
• All: 5 reference(s)