Tg(Myhca-Casq2)418Egk
Transgene Detail

Summary

• Symbol: Tg(Myhca-Casq2)418Egk
• Name: transgene insertion 418, Evangelia G Kranias
• MGI ID: MGI:3699603
• Transgene: Tg(Myhca-Casq2)418Egk Location: unknown
• Alliance: Tg(Myhca-Casq2)418Egk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myhca-Casq2)418Egk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Casq2 (MGI:1309469)

• Mutation details: This transgene constists of a 2180-bp fragment encompassing 60 bp of 5'-untranslated region, the entire mouse calsequestrin coding region, and 863 bp of 3'-untranslated region linked to the 3'-end of the mouse alpha myosin heavy chain (Myhca) promoter and to the blunted 5'-end of the human growth hormone polyadenylation signal sequence. Immunoblot analysis of cardiac homogenates revealed that cardiac calsequestrin protein levels were increased in transgenic mice compared to controls. Two additional transgenic lines, 398 and 412, were created in addition to line 418. (J:50498)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:50498 Sato Y, et al., Cardiac-specific overexpression of mouse cardiac calsequestrin is associated with depressed cardiovascular function and hypertrophy in transgenic mice. J Biol Chem. 1998 Oct 23;273(43):28470-7
• All: 5 reference(s)