Stk36^tm1Fjs
Targeted Allele Detail

Summary

• Symbol: Stk36^tm1Fjs
• Name: serine/threonine kinase 36; targeted mutation 1, Frederic J de Sauvage
• MGI ID: MGI:3699625
• Gene: Stk36 Location: Chr1:74640604-74676053 bp, + strand Genetic Position: Chr1, 38.54 cM, cytoband C3
• Alliance: Stk36^tm1Fjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116391
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace most of exon 3 through exon 12 with a neomycin resistance cassette. RT-PCR confirmed the lack of expression from the deleted sequence as well as from the endogenous sequence left intact. (J:116391)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk36 Mutation: 52 strains or lines available

References

• Original: J:116391 Merchant M, et al., Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol. 2005 Aug;25(16):7054-68
• All: 1 reference(s)