Fgd2^tm1Bgh
Targeted Allele Detail

Summary

• Symbol: Fgd2^tm1Bgh
• Name: FYVE, RhoGEF and PH domain containing 2; targeted mutation 1, Bernhard G Herrmann
• MGI ID: MGI:3699925
• Synonyms: Fgd2^tm4Bgh
• Gene: Fgd2 Location: Chr17:29579878-29598509 bp, + strand Genetic Position: Chr17, 15.26 cM
• Alliance: Fgd2^tm1Bgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117419
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BTBR

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Sequence encoding exons 3-6 and part of exon 7 was replaced with a neomycin resistance gene. (J:117419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgd2 Mutation: 34 strains or lines available

References

• Original: J:117419 Bauer H, et al., The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes Dev. 2007 Jan 15;21(2):143-7
• All: 1 reference(s)